DURAGESIC-25 vs PALLADONE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. DURAGESIC-25 and PALLADONE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DURAGESIC-25	PALLADONE
Rating	70/100	New
Pharmacy pays	$9.51 /mL	$0.57 /mL
Type	RX	RX
Active ingredient	FENTANYL	HYDROMORPHONE HYDROCHLORIDE
Manufacturer	Janssen Pharms	Purdue Pharma LP
Dosage forms	Film, extended release	Capsule, extended release
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	None	None
Half-life	—	about 2.3 hours (terminal elimination half-life after an intravenous dose); after an oral dose the label reports a mean T½ of about 2.6 hours for the 8 mg tablet and 2.8 hours for the oral liquid
Treats	Pain	Cough, Postoperative Pain

duragesic-25 palladone

Rating

70/100

New

Pharmacy pays

$9.51 /mL

$0.57 /mL

Type

Active ingredient

FENTANYL

HYDROMORPHONE HYDROCHLORIDE

Manufacturer

Janssen Pharms

Purdue Pharma LP

Dosage forms

Film, extended release

Capsule, extended release

Drug class

Opioid Agonist

Boxed warning

None

Half-life

—

about 2.3 hours (terminal elimination half-life after an intravenous dose); after an oral dose the label reports a mean T½ of about 2.6 hours for the 8 mg tablet and 2.8 hours for the oral liquid

Treats

Pain

Cough, Postoperative Pain

Frequently asked questions

Which is cheaper, Duragesic-25 or Palladone?

Palladone costs pharmacies less to acquire — about $0.57 vs $9.51 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Duragesic-25 and Palladone?

Duragesic-25 contains Fentanyl, while Palladone contains Hydromorphone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.