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DURAGESIC-12 vs SUBSYS

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Rating

70/100
New

Pharmacy pays

$9.51 /mL
$9.51 /mL

Type

RX
RX

Active ingredient

FENTANYL
FENTANYL

Dosage forms

Film, extended release
Spray/Inhaler

Drug class

Opioid Agonist
Opioid Agonist

Boxed warning

None
None

Treats

Pain
Pain

Frequently asked questions

Which is cheaper, Duragesic-12 or Subsys?

Pharmacies pay about the same to acquire either one — roughly $9.51 per ml, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Duragesic-12 and Subsys?

Both Duragesic-12 and Subsys share the active ingredient Fentanyl.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.