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DOXEPIN HYDROCHLORIDE vs PERTOFRANE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 16, 2026·How we rate

Possible drug interaction. DOXEPIN HYDROCHLORIDE and PERTOFRANE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

doxepin hydrochloridepertofrane

Rating

70/100
70/100

Pharmacy pays

~$4.84 /30
~$8.39 /30

Type

RX
RX

Active ingredient

DOXEPIN HYDROCHLORIDE
DESIPRAMINE HYDROCHLORIDE

Manufacturer

Watson Labs
Sanofi Aventis US

Dosage forms

Capsule, Topical, Solution, Tablet
Capsule

Drug class

Tricyclic Antidepressant
Tricyclic Antidepressant

Boxed warning

None
None

Half-life

about 8 to 24 hours (average about 17 hours)
—

Treats

Anxiety Disorders, Depressive Disorder, Atopic Dermatitis
Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Pain

Get doxepin hydrochloridehigher-rated option

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Frequently asked questions

Which is better-rated, Doxepin Hydrochloride or Pertofrane?

Doxepin Hydrochloride and Pertofrane are tied at 3.5 out of 5 by our independent rating.

Which is cheaper, Doxepin Hydrochloride or Pertofrane?

Doxepin Hydrochloride costs pharmacies less to acquire — about $4.84 vs $8.39 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Doxepin Hydrochloride and Pertofrane?

Doxepin Hydrochloride contains Doxepin Hydrochloride, while Pertofrane contains Desipramine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.