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DOLOPHINE HYDROCHLORIDE vs SUBSYS

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. DOLOPHINE HYDROCHLORIDE and SUBSYS are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

dolophine hydrochloridesubsys

Rating

72/100
New

Pharmacy pays

$0.18 /mL
$9.51 /mL

Type

RX
RX

Active ingredient

METHADONE HYDROCHLORIDE
FENTANYL

Manufacturer

Hikma
Btcp Pharma

Dosage forms

Tablet, Syrup
Spray/Inhaler

Drug class

Opioid Agonist
Opioid Agonist

Boxed warning

None
None

Half-life

about 8 to 59 hours (terminal/elimination half-life; a very wide range)
—

Treats

Opioid-Related Disorders, Intractable Pain
Pain

Frequently asked questions

Which is cheaper, Dolophine Hydrochloride or Subsys?

Dolophine Hydrochloride costs pharmacies less to acquire — about $0.18 vs $9.51 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Dolophine Hydrochloride and Subsys?

Dolophine Hydrochloride contains Methadone Hydrochloride, while Subsys contains Fentanyl — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.