DIPHENHYDRAMINE HYDROCHLORIDE vs UNISOM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. DIPHENHYDRAMINE HYDROCHLORIDE and UNISOM are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DIPHENHYDRAMINE HYDROCHLORIDE	UNISOM
Rating	New	64/100
Pharmacy pays	$0.04 /mL	—
Type	RX	RX
Active ingredient	DIPHENHYDRAMINE HYDROCHLORIDE	DOXYLAMINE SUCCINATE
Manufacturer	Alra	Pfizer
Dosage forms	Injectable, Solution, Capsule, Tablet	Capsule, Tablet
Drug class	Histamine-1 Receptor Antagonist	Antihistamine
Boxed warning	None	None
Treats	Anxiety Disorders, Sleep Initiation and Maintenance Disorders, Motion Sickness	Headache, Sleep Initiation and Maintenance Disorders, Perennial Allergic Rhinitis

diphenhydramine hydrochloride unisom

Rating

New

64/100

Pharmacy pays

$0.04 /mL

—

Type

Active ingredient

DIPHENHYDRAMINE HYDROCHLORIDE

DOXYLAMINE SUCCINATE

Manufacturer

Alra

Pfizer

Dosage forms

Injectable, Solution, Capsule, Tablet

Capsule, Tablet

Drug class

Histamine-1 Receptor Antagonist

Antihistamine

Boxed warning

None

Treats

Anxiety Disorders, Sleep Initiation and Maintenance Disorders, Motion Sickness

Headache, Sleep Initiation and Maintenance Disorders, Perennial Allergic Rhinitis

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Frequently asked questions

What is the difference between Diphenhydramine Hydrochloride and Unisom?

Diphenhydramine Hydrochloride contains Diphenhydramine Hydrochloride, while Unisom contains Doxylamine Succinate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.