DICLOFENAC SODIUM vs INDOMETHACIN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 14, 2026·How we rate

Possible drug interaction. DICLOFENAC SODIUM and INDOMETHACIN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DICLOFENAC SODIUM	INDOMETHACIN
Rating	70/100	72/100
Pharmacy pays	$0.36 /mL	~$4.06 /30
Type	RX	RX
Active ingredient	DICLOFENAC SODIUM	INDOMETHACIN
Manufacturer	Amneal	Rising
Dosage forms	Solution, Drops, Topical, Tablet, delayed release, Tablet, extended release, Tablet, Kit	Capsule, Capsule, extended release, Suppository
Drug class	Nonsteroidal Anti-Inflammatory Drug	Nonsteroidal Anti-Inflammatory Drug
Boxed warning	Boxed warning	None
Half-life	about 2 hours (terminal/elimination half-life; the label's table gives a mean of 2.3 hours in healthy adults, with wide variation between people — 48% coefficient of variation)	about 4.5 hours
Treats	Juvenile Arthritis, Rheumatoid Arthritis, Dysmenorrhea	Rheumatoid Arthritis, Bursitis, Patent Ductus Arteriosus

diclofenac sodium indomethacin

Rating

70/100

72/100

Pharmacy pays

$0.36 /mL

~$4.06 /30

Type

Active ingredient

DICLOFENAC SODIUM

INDOMETHACIN

Manufacturer

Amneal

Rising

Dosage forms

Solution, Drops, Topical, Tablet, delayed release, Tablet, extended release, Tablet, Kit

Capsule, Capsule, extended release, Suppository

Drug class

Nonsteroidal Anti-Inflammatory Drug

Boxed warning

None

Half-life

about 2 hours (terminal/elimination half-life; the label's table gives a mean of 2.3 hours in healthy adults, with wide variation between people — 48% coefficient of variation)

about 4.5 hours

Treats

Juvenile Arthritis, Rheumatoid Arthritis, Dysmenorrhea

Rheumatoid Arthritis, Bursitis, Patent Ductus Arteriosus

Frequently asked questions

Which is better-rated, Diclofenac Sodium or Indomethacin?

By our independent rating, Indomethacin scores higher — 3.6 vs 3.5 out of 5 for Diclofenac Sodium. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Diclofenac Sodium and Indomethacin?

Diclofenac Sodium contains Diclofenac Sodium, while Indomethacin contains Indomethacin — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.