DESYREL vs SELFEMRA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. DESYREL and SELFEMRA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DESYREL	SELFEMRA
Rating	New	56/100
Pharmacy pays	~$1.52 /30	$0.05 /mL
Type	RX	RX
Active ingredient	TRAZODONE HYDROCHLORIDE	FLUOXETINE HYDROCHLORIDE
Manufacturer	Pragma	Teva
Dosage forms	Tablet	Tablet
Drug class	Serotonin Reuptake Inhibitor	Serotonin Reuptake Inhibitor
Boxed warning	None	None
Half-life	about 7 hours (roughly 5 to 9 hours for the slower elimination phase)	about 1 to 3 days (roughly 24-72 hours) after a single dose, lengthening to about 4 to 6 days with ongoing daily use
Treats	Depressive Disorder, Sleep Initiation and Maintenance Disorders	Bulimia, Major Depressive Disorder, Obsessive-Compulsive Disorder

desyrel selfemra

Rating

New

56/100

Pharmacy pays

~$1.52 /30

$0.05 /mL

Type

Active ingredient

TRAZODONE HYDROCHLORIDE

FLUOXETINE HYDROCHLORIDE

Manufacturer

Pragma

Teva

Dosage forms

Tablet

Drug class

Serotonin Reuptake Inhibitor

Boxed warning

None

Half-life

about 7 hours (roughly 5 to 9 hours for the slower elimination phase)

about 1 to 3 days (roughly 24-72 hours) after a single dose, lengthening to about 4 to 6 days with ongoing daily use

Treats

Depressive Disorder, Sleep Initiation and Maintenance Disorders

Bulimia, Major Depressive Disorder, Obsessive-Compulsive Disorder

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Frequently asked questions

What is the difference between Desyrel and Selfemra?

Desyrel contains Trazodone Hydrochloride, while Selfemra contains Fluoxetine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.