DESYREL vs SARAFEM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. DESYREL and SARAFEM are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DESYREL	SARAFEM
Rating	New	New
Pharmacy pays	~$1.52 /30	$0.05 /mL
Type	RX	RX
Active ingredient	TRAZODONE HYDROCHLORIDE	FLUOXETINE HYDROCHLORIDE
Manufacturer	Pragma	Eli Lilly and Co
Dosage forms	Tablet	Capsule
Drug class	Serotonin Reuptake Inhibitor	Serotonin Reuptake Inhibitor
Boxed warning	None	Boxed warning
Half-life	about 7 hours (roughly 5 to 9 hours for the slower elimination phase)	about 1 to 3 days (roughly 24-72 hours) after a single dose, lengthening to about 4 to 6 days with ongoing daily use
Treats	Depressive Disorder, Sleep Initiation and Maintenance Disorders	Bulimia, Major Depressive Disorder, Obsessive-Compulsive Disorder

desyrel sarafem

Rating

New

Pharmacy pays

~$1.52 /30

$0.05 /mL

Type

Active ingredient

TRAZODONE HYDROCHLORIDE

FLUOXETINE HYDROCHLORIDE

Manufacturer

Pragma

Eli Lilly and Co

Dosage forms

Tablet

Capsule

Drug class

Serotonin Reuptake Inhibitor

Boxed warning

None

Boxed warning

Half-life

about 7 hours (roughly 5 to 9 hours for the slower elimination phase)

about 1 to 3 days (roughly 24-72 hours) after a single dose, lengthening to about 4 to 6 days with ongoing daily use

Treats

Depressive Disorder, Sleep Initiation and Maintenance Disorders

Bulimia, Major Depressive Disorder, Obsessive-Compulsive Disorder

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Frequently asked questions

What is the difference between Desyrel and Sarafem?

Desyrel contains Trazodone Hydrochloride, while Sarafem contains Fluoxetine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.