DESYREL vs PEXEVA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. DESYREL and PEXEVA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DESYREL	PEXEVA
Rating	New	New
Pharmacy pays	~$1.52 /30	~$2.84 /30
Type	RX	RX
Active ingredient	TRAZODONE HYDROCHLORIDE	PAROXETINE MESYLATE
Manufacturer	Pragma	Sebela Ireland Ltd
Dosage forms	Tablet	Tablet
Drug class	Serotonin Reuptake Inhibitor	Serotonin Reuptake Inhibitor
Boxed warning	None	None
Half-life	about 7 hours (roughly 5 to 9 hours for the slower elimination phase)	about 21 hours on average (the label reports a mean of approximately 21 hours, with 32% variability between people)
Treats	Depressive Disorder, Sleep Initiation and Maintenance Disorders	Feeding and Eating Disorders, Depressive Disorder, Obsessive-Compulsive Disorder

desyrel pexeva

Rating

New

Pharmacy pays

~$1.52 /30

~$2.84 /30

Type

Active ingredient

TRAZODONE HYDROCHLORIDE

PAROXETINE MESYLATE

Manufacturer

Pragma

Sebela Ireland Ltd

Dosage forms

Tablet

Drug class

Serotonin Reuptake Inhibitor

Boxed warning

None

Half-life

about 7 hours (roughly 5 to 9 hours for the slower elimination phase)

about 21 hours on average (the label reports a mean of approximately 21 hours, with 32% variability between people)

Treats

Depressive Disorder, Sleep Initiation and Maintenance Disorders

Feeding and Eating Disorders, Depressive Disorder, Obsessive-Compulsive Disorder

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Frequently asked questions

Which is cheaper, Desyrel or Pexeva?

Desyrel costs pharmacies less to acquire — about $1.52 vs $2.84 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Desyrel and Pexeva?

Desyrel contains Trazodone Hydrochloride, while Pexeva contains Paroxetine Mesylate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.