DESYREL vs PAXIL CR

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. DESYREL and PAXIL CR are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DESYREL	PAXIL CR
Rating	New	60/100
Pharmacy pays	~$1.52 /30	~$2.84 /30
Type	RX	RX
Active ingredient	TRAZODONE HYDROCHLORIDE	PAROXETINE HYDROCHLORIDE
Manufacturer	Pragma	Apotex
Dosage forms	Tablet	Tablet, extended release
Drug class	Serotonin Reuptake Inhibitor	Serotonin Reuptake Inhibitor
Boxed warning	None	Boxed warning
Half-life	about 7 hours (roughly 5 to 9 hours for the slower elimination phase)	about 21 hours on average (the label reports a mean of approximately 21 hours, with 32% variability between people)
Treats	Depressive Disorder, Sleep Initiation and Maintenance Disorders	Feeding and Eating Disorders, Depressive Disorder, Obsessive-Compulsive Disorder

desyrel paxil cr

Rating

New

60/100

Pharmacy pays

~$1.52 /30

~$2.84 /30

Type

Active ingredient

TRAZODONE HYDROCHLORIDE

PAROXETINE HYDROCHLORIDE

Manufacturer

Pragma

Apotex

Dosage forms

Tablet

Tablet, extended release

Drug class

Serotonin Reuptake Inhibitor

Boxed warning

None

Boxed warning

Half-life

about 7 hours (roughly 5 to 9 hours for the slower elimination phase)

about 21 hours on average (the label reports a mean of approximately 21 hours, with 32% variability between people)

Treats

Depressive Disorder, Sleep Initiation and Maintenance Disorders

Feeding and Eating Disorders, Depressive Disorder, Obsessive-Compulsive Disorder

Get paxil crhigher-rated option

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Frequently asked questions

Which is cheaper, Desyrel or Paxil CR?

Desyrel costs pharmacies less to acquire — about $1.52 vs $2.84 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Desyrel and Paxil CR?

Desyrel contains Trazodone Hydrochloride, while Paxil CR contains Paroxetine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.