DEPAKOTE CP vs ZONEGRAN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. DEPAKOTE CP and ZONEGRAN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DEPAKOTE CP	ZONEGRAN
Rating	70/100	New
Pharmacy pays	~$5.99 /30	~$3.16 /30
Type	RX	RX
Active ingredient	DIVALPROEX SODIUM	ZONISAMIDE
Manufacturer	Abbott	Advanz Pharma
Dosage forms	Tablet, delayed release	Capsule
Drug class	Anti-Epileptic Agent	Anti-Epileptic Agent
Boxed warning	None	None
Half-life	about 9 to 16 hours (the label's mean terminal half-life range for valproate monotherapy)	—
Treats	Bipolar Disorder, Epilepsy, Absence Epilepsy	Partial Epilepsies

depakote cp zonegran

Rating

70/100

New

Pharmacy pays

~$5.99 /30

~$3.16 /30

Type

Active ingredient

DIVALPROEX SODIUM

ZONISAMIDE

Manufacturer

Abbott

Advanz Pharma

Dosage forms

Tablet, delayed release

Capsule

Drug class

Anti-Epileptic Agent

Boxed warning

None

Half-life

about 9 to 16 hours (the label's mean terminal half-life range for valproate monotherapy)

—

Treats

Bipolar Disorder, Epilepsy, Absence Epilepsy

Partial Epilepsies

Frequently asked questions

Which is cheaper, Depakote Cp or Zonegran?

Zonegran costs pharmacies less to acquire — about $3.16 vs $5.99 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Depakote Cp and Zonegran?

Depakote Cp contains Divalproex Sodium, while Zonegran contains Zonisamide — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.