DECAPRYN vs HYDROXYZINE PAMOATE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 8, 2026·How we rate

Possible drug interaction. DECAPRYN and HYDROXYZINE PAMOATE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DECAPRYN	HYDROXYZINE PAMOATE
Rating	70/100	72/100
Pharmacy pays	—	—
Type	RX	RX
Active ingredient	DOXYLAMINE SUCCINATE	HYDROXYZINE PAMOATE
Manufacturer	Sanofi Aventis US	Watson Labs
Dosage forms	Tablet	Capsule
Drug class	Antihistamine	Antihistamine
Boxed warning	None	None
Half-life	—	about 14 to 20 hours in healthy adults (two reported mean values: 20.0 ± 4.1 hours and 14.0 hours)
Treats	Headache, Sleep Initiation and Maintenance Disorders, Perennial Allergic Rhinitis	Anxiety Disorders, Nausea, Pruritus

decapryn hydroxyzine pamoate

Rating

70/100

72/100

Pharmacy pays

—

Type

Active ingredient

DOXYLAMINE SUCCINATE

HYDROXYZINE PAMOATE

Manufacturer

Sanofi Aventis US

Watson Labs

Dosage forms

Tablet

Capsule

Drug class

Antihistamine

Boxed warning

None

Half-life

—

about 14 to 20 hours in healthy adults (two reported mean values: 20.0 ± 4.1 hours and 14.0 hours)

Treats

Headache, Sleep Initiation and Maintenance Disorders, Perennial Allergic Rhinitis

Anxiety Disorders, Nausea, Pruritus

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Frequently asked questions

Which is better-rated, Decapryn or Hydroxyzine Pamoate?

By our independent rating, Hydroxyzine Pamoate scores higher — 3.6 vs 3.5 out of 5 for Decapryn. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Decapryn and Hydroxyzine Pamoate?

Decapryn contains Doxylamine Succinate, while Hydroxyzine Pamoate contains Hydroxyzine Pamoate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.