DAYPRO vs INDOMETHACIN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 18, 2026·How we rate

Possible drug interaction. DAYPRO and INDOMETHACIN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DAYPRO	INDOMETHACIN
Rating	64/100	72/100
Pharmacy pays	~$17.64 /30	~$4.06 /30
Type	RX	RX
Active ingredient	OXAPROZIN	INDOMETHACIN
Manufacturer	Pfizer	Rising
Dosage forms	Tablet	Capsule, Capsule, extended release, Suppository
Drug class	Nonsteroidal Anti-Inflammatory Drug	Nonsteroidal Anti-Inflammatory Drug
Boxed warning	None	None
Half-life	—	about 4.5 hours
Treats	Juvenile Arthritis, Rheumatoid Arthritis, Osteoarthritis	Rheumatoid Arthritis, Bursitis, Patent Ductus Arteriosus

daypro indomethacin

Rating

64/100

72/100

Pharmacy pays

~$17.64 /30

~$4.06 /30

Type

Active ingredient

OXAPROZIN

INDOMETHACIN

Manufacturer

Pfizer

Rising

Dosage forms

Tablet

Capsule, Capsule, extended release, Suppository

Drug class

Nonsteroidal Anti-Inflammatory Drug

Boxed warning

None

Half-life

—

about 4.5 hours

Treats

Juvenile Arthritis, Rheumatoid Arthritis, Osteoarthritis

Rheumatoid Arthritis, Bursitis, Patent Ductus Arteriosus

Frequently asked questions

Which is better-rated, Daypro or Indomethacin?

By our independent rating, Indomethacin scores higher — 3.6 vs 3.2 out of 5 for Daypro. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Daypro or Indomethacin?

Indomethacin costs pharmacies less to acquire — about $4.06 vs $17.64 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Daypro and Indomethacin?

Daypro contains Oxaprozin, while Indomethacin contains Indomethacin — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.