CUPRIMINE vs XTRELUS

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 6, 2026·How we rate

Possible drug interaction. CUPRIMINE and XTRELUS are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	CUPRIMINE	XTRELUS
Rating	74/100	New
Pharmacy pays	—	$0.07 /mL
Type	RX	RX
Active ingredient	PENICILLAMINE	GUAIFENESIN AND HYDROCODONE BITARTRATE
Manufacturer	Valeant Pharm Intl	Eci Pharms LLC
Dosage forms	Capsule	Tablet
Drug class	Antirheumatic Agent	—
Boxed warning	Boxed warning	None
Half-life	—	about 3.8 hours (3.8 ± 0.3 hours)
Treats	Rheumatoid Arthritis, Cystinuria, Hepatolenticular Degeneration	—

cuprimine xtrelus

Rating

74/100

New

Pharmacy pays

—

$0.07 /mL

Type

Active ingredient

PENICILLAMINE

GUAIFENESIN AND HYDROCODONE BITARTRATE

Manufacturer

Valeant Pharm Intl

Eci Pharms LLC

Dosage forms

Capsule

Tablet

Drug class

Antirheumatic Agent

—

Boxed warning

None

Half-life

—

about 3.8 hours (3.8 ± 0.3 hours)

Treats

Rheumatoid Arthritis, Cystinuria, Hepatolenticular Degeneration

—

Frequently asked questions

What is the difference between Cuprimine and Xtrelus?

Cuprimine contains Penicillamine, while Xtrelus contains Guaifenesin and Hydrocodone Bitartrate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.