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COMPAZINE vs PROMETHAZINE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. COMPAZINE and PROMETHAZINE HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

compazinepromethazine hydrochloride

Rating

70/100
New

Pharmacy pays

~$5.22 /30
~$1.53 /30

Type

RX
RX

Active ingredient

PROCHLORPERAZINE MALEATE
PROMETHAZINE HYDROCHLORIDE

Manufacturer

Glaxosmithkline
Sun Pharm Inds Inc

Dosage forms

Capsule, extended release, Tablet, Suppository
Injectable, Solution, Syrup, Tablet

Drug class

Phenothiazine
Phenothiazine

Boxed warning

None
None

Half-life

—
about 9 to 16 hours

Treats

Anxiety Disorders, Dementia, Nausea
Anaphylaxis, Allergic Conjunctivitis, Motion Sickness

Frequently asked questions

Which is cheaper, Compazine or Promethazine Hydrochloride?

Promethazine Hydrochloride costs pharmacies less to acquire — about $1.53 vs $5.22 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Compazine and Promethazine Hydrochloride?

Compazine contains Prochlorperazine Maleate, while Promethazine Hydrochloride contains Promethazine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.