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COLAZAL vs POLY-PRED

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 7, 2026·How we rate

Possible drug interaction. COLAZAL and POLY-PRED are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

74/100
72/100

Pharmacy pays

~$11.02 /30
~$25.36 /30

Type

RX
RX

Active ingredient

BALSALAZIDE DISODIUM
NEOMYCIN SULFATE AND POLYMYXIN B SULFATE AND PREDNISOLONE ACETATE

Dosage forms

Capsule
Drops

Drug class

Aminosalicylate
—

Boxed warning

None
None

Half-life

—
2 to 4 hours

Treats

Ulcerative Colitis
—

Frequently asked questions

Which is better-rated, Colazal or Poly-Pred?

By our independent rating, Colazal scores higher — 3.7 vs 3.6 out of 5 for Poly-Pred. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Colazal or Poly-Pred?

Colazal costs pharmacies less to acquire — about $11.02 vs $25.36 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Colazal and Poly-Pred?

Colazal contains Balsalazide Disodium, while Poly-Pred contains Neomycin Sulfate and Polymyxin B Sulfate and Prednisolone Acetate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.