CLOZARIL vs SAPHRIS

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Possible drug interaction. CLOZARIL and SAPHRIS are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	CLOZARIL	SAPHRIS
Rating	New	70/100
Pharmacy pays	~$30.62 /30	~$73.98 /30
Type	RX	RX
Active ingredient	CLOZAPINE	ASENAPINE MALEATE
Manufacturer	Heritage Life	Abbvie
Dosage forms	Tablet	Tablet
Drug class	Atypical Antipsychotic	Atypical Antipsychotic
Boxed warning	Boxed warning	Boxed warning
Half-life	about 12 hours at steady state (the label gives a mean elimination half-life of 12 hours, range 4 to 66 hours, after 100 mg twice daily); after a single 75 mg dose the mean is 8 hours (range 4 to 12 hours)	about 24 hours (terminal/elimination half-life)
Treats	Bipolar Disorder, Psychotic Disorders, Schizophrenia	Bipolar Disorder, Schizophrenia

clozaril saphris

Rating

New

70/100

Pharmacy pays

~$30.62 /30

~$73.98 /30

Type

Active ingredient

CLOZAPINE

ASENAPINE MALEATE

Manufacturer

Heritage Life

Abbvie

Dosage forms

Tablet

Drug class

Atypical Antipsychotic

Boxed warning

Half-life

about 12 hours at steady state (the label gives a mean elimination half-life of 12 hours, range 4 to 66 hours, after 100 mg twice daily); after a single 75 mg dose the mean is 8 hours (range 4 to 12 hours)

about 24 hours (terminal/elimination half-life)

Treats

Bipolar Disorder, Psychotic Disorders, Schizophrenia

Bipolar Disorder, Schizophrenia

Frequently asked questions

Which is cheaper, Clozaril or Saphris?

Clozaril costs pharmacies less to acquire — about $30.62 vs $73.98 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Clozaril and Saphris?

Clozaril contains Clozapine, while Saphris contains Asenapine Maleate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.