CLOTRIMAZOLE vs NYSTATIN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 7, 2026·How we rate

Possible drug interaction. CLOTRIMAZOLE and NYSTATIN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	CLOTRIMAZOLE	NYSTATIN
Rating	72/100	68/100
Pharmacy pays	$0.21 /mL	$0.24 /g
Type	RX	RX
Active ingredient	CLOTRIMAZOLE	NYSTATIN
Manufacturer	Fougera Pharms	Sandoz
Dosage forms	Topical, Lozenge, Solution, Spray/Inhaler	Topical, Powder, Suspension, Tablet
Drug class	Azole Antifungal	Polyene Antifungal
Boxed warning	None	None
Treats	Cutaneous Candidiasis, Oral Candidiasis, Vulvovaginal Candidiasis	Chronic Mucocutaneous Candidiasis, Cutaneous Candidiasis, Oral Candidiasis

clotrimazole nystatin

Rating

72/100

68/100

Pharmacy pays

$0.21 /mL

$0.24 /g

Type

Active ingredient

CLOTRIMAZOLE

NYSTATIN

Manufacturer

Fougera Pharms

Sandoz

Dosage forms

Topical, Lozenge, Solution, Spray/Inhaler

Topical, Powder, Suspension, Tablet

Drug class

Azole Antifungal

Polyene Antifungal

Boxed warning

None

Treats

Cutaneous Candidiasis, Oral Candidiasis, Vulvovaginal Candidiasis

Chronic Mucocutaneous Candidiasis, Cutaneous Candidiasis, Oral Candidiasis

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Frequently asked questions

Which is better-rated, Clotrimazole or Nystatin?

By our independent rating, Clotrimazole scores higher — 3.6 vs 3.4 out of 5 for Nystatin. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Clotrimazole and Nystatin?

Clotrimazole contains Clotrimazole, while Nystatin contains Nystatin — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.