Skip to content
ppharmaranks
Menu

CLOTRIMAZOLE vs DIFLUCAN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 18, 2026·How we rate

Possible drug interaction. CLOTRIMAZOLE and DIFLUCAN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

70/100
60/100

Pharmacy pays

$0.21 /mL
$0.42 /mL

Type

RX
RX

Active ingredient

CLOTRIMAZOLE
FLUCONAZOLE

Dosage forms

Topical, Lozenge, Solution, Spray/Inhaler
Powder

Drug class

Azole Antifungal
Azole Antifungal

Boxed warning

None
None

Half-life

about 30 hours (range 20 to 50 hours)

Treats

Cutaneous Candidiasis, Oral Candidiasis, Vulvovaginal Candidiasis
Blastomycosis, Chronic Mucocutaneous Candidiasis, Oral Candidiasis

Get clotrimazolehigher-rated option

Advertising disclosure: Some links are affiliate links. We may earn a commission at no extra cost to you. This never affects our independent ratings.

Get treatment online

Licensed online providers — consult & get prescribed if eligible.

Frequently asked questions

Which is better-rated, Clotrimazole or Diflucan?

By our independent rating, Clotrimazole scores higher — 3.5 vs 3.0 out of 5 for Diflucan. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Clotrimazole or Diflucan?

Clotrimazole costs pharmacies less to acquire — about $0.21 vs $0.42 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Clotrimazole and Diflucan?

Clotrimazole contains Clotrimazole, while Diflucan contains Fluconazole — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.