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CLOTIC vs LOTRIMIN AF

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Rating

New
New

Pharmacy pays

$0.21 /mL
$0.21 /mL

Type

RX
OTC

Active ingredient

CLOTRIMAZOLE
CLOTRIMAZOLE

Dosage forms

Liquid
Spray/Inhaler

Drug class

Azole Antifungal
Azole Antifungal

Boxed warning

None
None

Treats

Cutaneous Candidiasis, Oral Candidiasis, Vulvovaginal Candidiasis
Cutaneous Candidiasis, Oral Candidiasis, Vulvovaginal Candidiasis

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Frequently asked questions

Which is cheaper, Clotic or Lotrimin Af?

Pharmacies pay about the same to acquire either one — roughly $0.21 per ml, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Clotic and Lotrimin Af?

Both Clotic and Lotrimin Af share the active ingredient Clotrimazole, but Clotic is sold as RX and Lotrimin Af as OTC.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.