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CLODERM vs CORTENEMA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. CLODERM and CORTENEMA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

New
70/100

Pharmacy pays

$5.21 /g
$0.15 /g

Type

RX
RX

Active ingredient

CLOCORTOLONE PIVALATE
HYDROCORTISONE

Dosage forms

Topical
Enema

Drug class

Corticosteroid
Corticosteroid

Boxed warning

None
None

Half-life

about 1.5 hours

Treats

Facial Dermatoses, Foot Dermatoses, Hand Dermatoses
Adrenal Insufficiency, Congenital Adrenal Hyperplasia, Ulcerative Colitis

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Frequently asked questions

Which is cheaper, Cloderm or Cortenema?

Cortenema costs pharmacies less to acquire — about $0.15 vs $5.21 per gm, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Cloderm and Cortenema?

Cloderm contains Clocortolone Pivalate, while Cortenema contains Hydrocortisone — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.