CHLORPHENIRAMINE MALEATE vs ZYRTEC

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Attribute	CHLORPHENIRAMINE MALEATE	ZYRTEC
Rating	New	New
Pharmacy pays	—	$0.06 /mL
Type	RX	OTC
Active ingredient	CHLORPHENIRAMINE MALEATE	CETIRIZINE HYDROCHLORIDE
Manufacturer	Roxane	—
Dosage forms	Tablet	Tablet, chewable
Drug class	Histamine-1 Receptor Antagonist	Histamine-1 Receptor Antagonist
Boxed warning	None	None
Half-life	—	about 8.3 hours (mean in healthy adults)
Treats	Perennial Allergic Rhinitis, Urticaria	Perennial Allergic Rhinitis, Urticaria

chlorpheniramine maleate zyrtec

Rating

New

Pharmacy pays

—

$0.06 /mL

Type

OTC

Active ingredient

CHLORPHENIRAMINE MALEATE

CETIRIZINE HYDROCHLORIDE

Manufacturer

Roxane

—

Dosage forms

Tablet

Tablet, chewable

Drug class

Histamine-1 Receptor Antagonist

Boxed warning

None

Half-life

—

about 8.3 hours (mean in healthy adults)

Treats

Perennial Allergic Rhinitis, Urticaria

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Frequently asked questions

What is the difference between Chlorpheniramine Maleate and Zyrtec?

Chlorpheniramine Maleate contains Chlorpheniramine Maleate, while Zyrtec contains Cetirizine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.