CABOMETYX vs ZORTRESS

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. CABOMETYX and ZORTRESS are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	CABOMETYX	ZORTRESS
Rating	New	70/100
Pharmacy pays	—	~$229.16 /30
Type	RX	RX
Active ingredient	CABOZANTINIB S-MALATE	EVEROLIMUS
Manufacturer	Exelixis	Novartis
Dosage forms	Tablet	Tablet
Drug class	Kinase Inhibitor	Kinase Inhibitor
Boxed warning	None	Boxed warning
Half-life	—	about 30 hours (mean terminal elimination half-life)
Treats	Renal Cell Carcinoma	—

cabometyx zortress

Rating

New

70/100

Pharmacy pays

—

~$229.16 /30

Type

Active ingredient

CABOZANTINIB S-MALATE

EVEROLIMUS

Manufacturer

Exelixis

Novartis

Dosage forms

Tablet

Drug class

Kinase Inhibitor

Boxed warning

None

Boxed warning

Half-life

—

about 30 hours (mean terminal elimination half-life)

Treats

Renal Cell Carcinoma

—

Frequently asked questions

What is the difference between Cabometyx and Zortress?

Cabometyx contains Cabozantinib S-Malate, while Zortress contains Everolimus — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.