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BUTORPHANOL TARTRATE PRESERVATIVE FREE vs NUBAIN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. BUTORPHANOL TARTRATE PRESERVATIVE FREE and NUBAIN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

60/100
New

Pharmacy pays

$14.72 /mL
$4.32 /mL

Type

RX
RX

Active ingredient

BUTORPHANOL TARTRATE
NALBUPHINE HYDROCHLORIDE

Manufacturer

Dosage forms

Injectable
Solution

Drug class

Opioid Agonist/Antagonist
Opioid Agonist/Antagonist

Boxed warning

None
None

Treats

Pain
Postoperative Pain

Frequently asked questions

Which is cheaper, Butorphanol Tartrate Preservative Free or Nubain?

Nubain costs pharmacies less to acquire — about $4.32 vs $14.72 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Butorphanol Tartrate Preservative Free and Nubain?

Butorphanol Tartrate Preservative Free contains Butorphanol Tartrate, while Nubain contains Nalbuphine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.