BUSULFEX vs GLEOSTINE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. BUSULFEX and GLEOSTINE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	BUSULFEX	GLEOSTINE
Rating	New	70/100
Pharmacy pays	—	—
Type	RX	RX
Active ingredient	BUSULFAN	LOMUSTINE
Manufacturer	Otsuka	Azurity
Dosage forms	Injectable	Capsule
Drug class	Alkylating Drug	Alkylating Drug
Boxed warning	None	Boxed warning
Half-life	—	about 16 to 48 hours — but note this is the half-life of lomustine's metabolites, not the parent drug
Treats	Polycythemia Vera, Bcr-Abl Positive Chronic Myelogenous Leukemia, Primary Myelofibrosis	Brain Neoplasms, Colonic Neoplasms, Hodgkin Disease

busulfex gleostine

Rating

New

70/100

Pharmacy pays

—

Type

Active ingredient

BUSULFAN

LOMUSTINE

Manufacturer

Otsuka

Azurity

Dosage forms

Injectable

Capsule

Drug class

Alkylating Drug

Boxed warning

None

Boxed warning

Half-life

—

about 16 to 48 hours — but note this is the half-life of lomustine's metabolites, not the parent drug

Treats

Polycythemia Vera, Bcr-Abl Positive Chronic Myelogenous Leukemia, Primary Myelofibrosis

Brain Neoplasms, Colonic Neoplasms, Hodgkin Disease

Frequently asked questions

What is the difference between Busulfex and Gleostine?

Busulfex contains Busulfan, while Gleostine contains Lomustine — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.