BICILLIN vs PROSTAPHLIN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. BICILLIN and PROSTAPHLIN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	BICILLIN	PROSTAPHLIN
Rating	New	New
Pharmacy pays	—	—
Type	RX	RX
Active ingredient	PENICILLIN G BENZATHINE	OXACILLIN SODIUM
Manufacturer	Wyeth Ayerst	Apothecon
Dosage forms	Suspension, Tablet	Capsule
Drug class	Penicillin-Class Antibacterial	Penicillin-Class Antibacterial
Boxed warning	None	None
Treats	Actinomycosis, Anthrax, Botulism	Cellulitis, Bacterial Endocarditis, Osteomyelitis

bicillin prostaphlin

Rating

New

Pharmacy pays

—

Type

Active ingredient

PENICILLIN G BENZATHINE

OXACILLIN SODIUM

Manufacturer

Wyeth Ayerst

Apothecon

Dosage forms

Suspension, Tablet

Capsule

Drug class

Penicillin-Class Antibacterial

Boxed warning

None

Treats

Actinomycosis, Anthrax, Botulism

Cellulitis, Bacterial Endocarditis, Osteomyelitis

Frequently asked questions

What is the difference between Bicillin and Prostaphlin?

Bicillin contains Penicillin G Benzathine, while Prostaphlin contains Oxacillin Sodium — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.