BICILLIN vs NAFCILLIN SODIUM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. BICILLIN and NAFCILLIN SODIUM are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	BICILLIN	NAFCILLIN SODIUM
Rating	New	New
Pharmacy pays	—	—
Type	RX	RX
Active ingredient	PENICILLIN G BENZATHINE	NAFCILLIN SODIUM
Manufacturer	Wyeth Ayerst	Fresenius
Dosage forms	Suspension, Tablet	Injectable
Drug class	Penicillin-Class Antibacterial	Penicillin-Class Antibacterial
Boxed warning	None	None
Treats	Actinomycosis, Anthrax, Botulism	Cellulitis, Bacterial Endocarditis, Osteomyelitis

bicillin nafcillin sodium

Rating

New

Pharmacy pays

—

Type

Active ingredient

PENICILLIN G BENZATHINE

NAFCILLIN SODIUM

Manufacturer

Wyeth Ayerst

Fresenius

Dosage forms

Suspension, Tablet

Injectable

Drug class

Penicillin-Class Antibacterial

Boxed warning

None

Treats

Actinomycosis, Anthrax, Botulism

Cellulitis, Bacterial Endocarditis, Osteomyelitis

Frequently asked questions

What is the difference between Bicillin and Nafcillin Sodium?

Bicillin contains Penicillin G Benzathine, while Nafcillin Sodium contains Nafcillin Sodium — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.