BETAPACE AF vs RYTHMOL

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. BETAPACE AF and RYTHMOL are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	BETAPACE AF	RYTHMOL
Rating	New	70/100
Pharmacy pays	~$2.96 /30	~$10.51 /30
Type	RX	RX
Active ingredient	SOTALOL HYDROCHLORIDE	PROPAFENONE HYDROCHLORIDE
Manufacturer	Legacy Pharma	Glaxosmithkline
Dosage forms	Tablet	Tablet
Drug class	Antiarrhythmic	Antiarrhythmic
Boxed warning	Boxed warning	None
Half-life	about 12 hours (the label gives a mean elimination half-life of 12 hours)	about 2 to 10 hours (immediate-release) in the ~90% of adults who are extensive CYP2D6 metabolizers
Treats	Atrial Fibrillation, Atrial Flutter, Supraventricular Tachycardia	Atrial Fibrillation, Supraventricular Tachycardia

betapace af rythmol

Rating

New

70/100

Pharmacy pays

~$2.96 /30

~$10.51 /30

Type

Active ingredient

SOTALOL HYDROCHLORIDE

PROPAFENONE HYDROCHLORIDE

Manufacturer

Legacy Pharma

Glaxosmithkline

Dosage forms

Tablet

Drug class

Antiarrhythmic

Boxed warning

None

Half-life

about 12 hours (the label gives a mean elimination half-life of 12 hours)

about 2 to 10 hours (immediate-release) in the ~90% of adults who are extensive CYP2D6 metabolizers

Treats

Atrial Fibrillation, Atrial Flutter, Supraventricular Tachycardia

Atrial Fibrillation, Supraventricular Tachycardia

Frequently asked questions

Which is cheaper, Betapace Af or Rythmol?

Betapace Af costs pharmacies less to acquire — about $2.96 vs $10.51 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Betapace Af and Rythmol?

Betapace Af contains Sotalol Hydrochloride, while Rythmol contains Propafenone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.