BENADRYL PRESERVATIVE FREE vs XYZAL ALLERGY 24HR

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Attribute	BENADRYL PRESERVATIVE FREE	XYZAL ALLERGY 24HR
Rating	New	New
Pharmacy pays	$0.04 /mL	$0.06 /mL
Type	RX	OTC
Active ingredient	DIPHENHYDRAMINE HYDROCHLORIDE	LEVOCETIRIZINE DIHYDROCHLORIDE
Manufacturer	Mcneil Cons	Chattem Sanofi
Dosage forms	Injectable	Tablet
Drug class	Histamine-1 Receptor Antagonist	Histamine-1 Receptor Antagonist
Boxed warning	None	None
Treats	Anxiety Disorders, Sleep Initiation and Maintenance Disorders, Motion Sickness	Seasonal Allergic Rhinitis, Perennial Allergic Rhinitis, Urticaria

benadryl preservative free xyzal allergy 24hr

Rating

New

Pharmacy pays

$0.04 /mL

$0.06 /mL

Type

OTC

Active ingredient

DIPHENHYDRAMINE HYDROCHLORIDE

LEVOCETIRIZINE DIHYDROCHLORIDE

Manufacturer

Mcneil Cons

Chattem Sanofi

Dosage forms

Injectable

Tablet

Drug class

Histamine-1 Receptor Antagonist

Boxed warning

None

Treats

Anxiety Disorders, Sleep Initiation and Maintenance Disorders, Motion Sickness

Seasonal Allergic Rhinitis, Perennial Allergic Rhinitis, Urticaria

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Frequently asked questions

Which is cheaper, Benadryl Preservative Free or Xyzal Allergy 24hr?

Benadryl Preservative Free costs pharmacies less to acquire — about $0.04 vs $0.06 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Benadryl Preservative Free and Xyzal Allergy 24hr?

Benadryl Preservative Free contains Diphenhydramine Hydrochloride, while Xyzal Allergy 24hr contains Levocetirizine Dihydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.