BENADRYL PRESERVATIVE FREE vs PATANASE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. BENADRYL PRESERVATIVE FREE and PATANASE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	BENADRYL PRESERVATIVE FREE	PATANASE
Rating	New	70/100
Pharmacy pays	$0.04 /mL	$1.23 /g
Type	RX	RX
Active ingredient	DIPHENHYDRAMINE HYDROCHLORIDE	OLOPATADINE HYDROCHLORIDE
Manufacturer	Mcneil Cons	Novartis
Dosage forms	Injectable	Spray/Inhaler, metered
Drug class	Histamine-1 Receptor Antagonist	Histamine-1 Receptor Antagonist
Boxed warning	None	None
Treats	Anxiety Disorders, Sleep Initiation and Maintenance Disorders, Motion Sickness	Allergic Conjunctivitis

benadryl preservative free patanase

Rating

New

70/100

Pharmacy pays

$0.04 /mL

$1.23 /g

Type

Active ingredient

DIPHENHYDRAMINE HYDROCHLORIDE

OLOPATADINE HYDROCHLORIDE

Manufacturer

Mcneil Cons

Novartis

Dosage forms

Injectable

Spray/Inhaler, metered

Drug class

Histamine-1 Receptor Antagonist

Boxed warning

None

Treats

Anxiety Disorders, Sleep Initiation and Maintenance Disorders, Motion Sickness

Allergic Conjunctivitis

Frequently asked questions

What is the difference between Benadryl Preservative Free and Patanase?

Benadryl Preservative Free contains Diphenhydramine Hydrochloride, while Patanase contains Olopatadine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.