BENADRYL PRESERVATIVE FREE vs PATADAY ONCE DAILY RELIEF

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Attribute	BENADRYL PRESERVATIVE FREE	PATADAY ONCE DAILY RELIEF
Rating	New	New
Pharmacy pays	$0.04 /mL	$1.23 /g
Type	RX	OTC
Active ingredient	DIPHENHYDRAMINE HYDROCHLORIDE	OLOPATADINE HYDROCHLORIDE
Manufacturer	Mcneil Cons	Alcon
Dosage forms	Injectable	Solution
Drug class	Histamine-1 Receptor Antagonist	Histamine-1 Receptor Antagonist
Boxed warning	None	None
Treats	Anxiety Disorders, Sleep Initiation and Maintenance Disorders, Motion Sickness	Allergic Conjunctivitis

benadryl preservative free pataday once daily relief

Rating

New

Pharmacy pays

$0.04 /mL

$1.23 /g

Type

OTC

Active ingredient

DIPHENHYDRAMINE HYDROCHLORIDE

OLOPATADINE HYDROCHLORIDE

Manufacturer

Mcneil Cons

Alcon

Dosage forms

Injectable

Solution

Drug class

Histamine-1 Receptor Antagonist

Boxed warning

None

Treats

Anxiety Disorders, Sleep Initiation and Maintenance Disorders, Motion Sickness

Allergic Conjunctivitis

Get pataday once daily relief

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Frequently asked questions

What is the difference between Benadryl Preservative Free and Pataday Once Daily Relief?

Benadryl Preservative Free contains Diphenhydramine Hydrochloride, while Pataday Once Daily Relief contains Olopatadine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.