BENADRYL PRESERVATIVE FREE vs OLOPATADINE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Possible drug interaction. BENADRYL PRESERVATIVE FREE and OLOPATADINE HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	BENADRYL PRESERVATIVE FREE	OLOPATADINE HYDROCHLORIDE
Rating	New	66/100
Pharmacy pays	$0.04 /mL	$1.23 /g
Type	RX	RX
Active ingredient	DIPHENHYDRAMINE HYDROCHLORIDE	OLOPATADINE HYDROCHLORIDE
Manufacturer	Mcneil Cons	Apotex
Dosage forms	Injectable	Solution, Drops, Spray/Inhaler, Spray/Inhaler, metered
Drug class	Histamine-1 Receptor Antagonist	Histamine-1 Receptor Antagonist
Boxed warning	None	None
Treats	Anxiety Disorders, Sleep Initiation and Maintenance Disorders, Motion Sickness	Allergic Conjunctivitis

benadryl preservative free olopatadine hydrochloride

Rating

New

66/100

Pharmacy pays

$0.04 /mL

$1.23 /g

Type

Active ingredient

DIPHENHYDRAMINE HYDROCHLORIDE

OLOPATADINE HYDROCHLORIDE

Manufacturer

Mcneil Cons

Apotex

Dosage forms

Injectable

Solution, Drops, Spray/Inhaler, Spray/Inhaler, metered

Drug class

Histamine-1 Receptor Antagonist

Boxed warning

None

Treats

Anxiety Disorders, Sleep Initiation and Maintenance Disorders, Motion Sickness

Allergic Conjunctivitis

Frequently asked questions

What is the difference between Benadryl Preservative Free and Olopatadine Hydrochloride?

Benadryl Preservative Free contains Diphenhydramine Hydrochloride, while Olopatadine Hydrochloride contains Olopatadine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.