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BENADRYL PRESERVATIVE FREE vs LEVOCETIRIZINE DIHYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate
benadryl preservative freelevocetirizine dihydrochloride

Rating

New
New

Pharmacy pays

$0.04 /mL
$0.06 /mL

Type

RX
OTC

Active ingredient

DIPHENHYDRAMINE HYDROCHLORIDE
LEVOCETIRIZINE DIHYDROCHLORIDE

Manufacturer

Mcneil Cons
Dr Reddys

Dosage forms

Injectable
Solution, Tablet

Drug class

Histamine-1 Receptor Antagonist
Histamine-1 Receptor Antagonist

Boxed warning

None
None

Treats

Anxiety Disorders, Sleep Initiation and Maintenance Disorders, Motion Sickness
Seasonal Allergic Rhinitis, Perennial Allergic Rhinitis, Urticaria

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Frequently asked questions

Which is cheaper, Benadryl Preservative Free or Levocetirizine Dihydrochloride?

Benadryl Preservative Free costs pharmacies less to acquire — about $0.04 vs $0.06 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Benadryl Preservative Free and Levocetirizine Dihydrochloride?

Benadryl Preservative Free contains Diphenhydramine Hydrochloride, while Levocetirizine Dihydrochloride contains Levocetirizine Dihydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.