BENADRYL PRESERVATIVE FREE vs FEXOFENADINE HYDROCHLORIDE HIVES

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Attribute	BENADRYL PRESERVATIVE FREE	FEXOFENADINE HYDROCHLORIDE HIVES
Rating	New	New
Pharmacy pays	$0.04 /mL	~$7.33 /30
Type	RX	OTC
Active ingredient	DIPHENHYDRAMINE HYDROCHLORIDE	FEXOFENADINE HYDROCHLORIDE
Manufacturer	Mcneil Cons	Sun Pharm Inds Inc
Dosage forms	Injectable	Tablet
Drug class	Histamine-1 Receptor Antagonist	Histamine-1 Receptor Antagonist
Boxed warning	None	None
Half-life	—	about 14 hours (label: mean elimination half-life 14.4 hours)
Treats	Anxiety Disorders, Sleep Initiation and Maintenance Disorders, Motion Sickness	Perennial Allergic Rhinitis, Urticaria

benadryl preservative free fexofenadine hydrochloride hives

Rating

New

Pharmacy pays

$0.04 /mL

~$7.33 /30

Type

OTC

Active ingredient

DIPHENHYDRAMINE HYDROCHLORIDE

FEXOFENADINE HYDROCHLORIDE

Manufacturer

Mcneil Cons

Sun Pharm Inds Inc

Dosage forms

Injectable

Tablet

Drug class

Histamine-1 Receptor Antagonist

Boxed warning

None

Half-life

—

about 14 hours (label: mean elimination half-life 14.4 hours)

Treats

Anxiety Disorders, Sleep Initiation and Maintenance Disorders, Motion Sickness

Perennial Allergic Rhinitis, Urticaria

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Frequently asked questions

What is the difference between Benadryl Preservative Free and Fexofenadine Hydrochloride Hives?

Benadryl Preservative Free contains Diphenhydramine Hydrochloride, while Fexofenadine Hydrochloride Hives contains Fexofenadine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.