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AZELASTINE HYDROCHLORIDE vs BENADRYL PRESERVATIVE FREE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. AZELASTINE HYDROCHLORIDE and BENADRYL PRESERVATIVE FREE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

New
New

Pharmacy pays

$0.58 /mL
$0.04 /mL

Type

RX
RX

Active ingredient

AZELASTINE HYDROCHLORIDE
DIPHENHYDRAMINE HYDROCHLORIDE

Manufacturer

Dosage forms

Drops, Spray/Inhaler, metered
Injectable

Drug class

Histamine-1 Receptor Antagonist
Histamine-1 Receptor Antagonist

Boxed warning

None
None

Treats

Allergic Conjunctivitis, Perennial Allergic Rhinitis, Vasomotor Rhinitis
Anxiety Disorders, Sleep Initiation and Maintenance Disorders, Motion Sickness

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Frequently asked questions

Which is cheaper, Azelastine Hydrochloride or Benadryl Preservative Free?

Benadryl Preservative Free costs pharmacies less to acquire — about $0.04 vs $0.58 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Azelastine Hydrochloride and Benadryl Preservative Free?

Azelastine Hydrochloride contains Azelastine Hydrochloride, while Benadryl Preservative Free contains Diphenhydramine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.