AVENTYL vs PERTOFRANE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 16, 2026·How we rate

Possible drug interaction. AVENTYL and PERTOFRANE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	AVENTYL	PERTOFRANE
Rating	72/100	70/100
Pharmacy pays	$0.17 /mL	~$8.39 /30
Type	RX	RX
Active ingredient	NORTRIPTYLINE HYDROCHLORIDE	DESIPRAMINE HYDROCHLORIDE
Manufacturer	Ranbaxy	Sanofi Aventis US
Dosage forms	Solution	Capsule
Drug class	Tricyclic Antidepressant	Tricyclic Antidepressant
Boxed warning	None	None
Treats	Anxiety Disorders, Attention Deficit Disorder with Hyperactivity, Depressive Disorder	Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Pain

aventyl pertofrane

Rating

72/100

70/100

Pharmacy pays

$0.17 /mL

~$8.39 /30

Type

Active ingredient

NORTRIPTYLINE HYDROCHLORIDE

DESIPRAMINE HYDROCHLORIDE

Manufacturer

Ranbaxy

Sanofi Aventis US

Dosage forms

Solution

Capsule

Drug class

Tricyclic Antidepressant

Boxed warning

None

Treats

Anxiety Disorders, Attention Deficit Disorder with Hyperactivity, Depressive Disorder

Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Pain

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Frequently asked questions

Which is better-rated, Aventyl or Pertofrane?

By our independent rating, Aventyl scores higher — 3.6 vs 3.5 out of 5 for Pertofrane. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Aventyl and Pertofrane?

Aventyl contains Nortriptyline Hydrochloride, while Pertofrane contains Desipramine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.