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ASTEPRO ALLERGY vs DIPHENHYDRAMINE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Rating

New
New

Pharmacy pays

$0.58 /mL
$0.04 /mL

Type

OTC
RX

Active ingredient

AZELASTINE HYDROCHLORIDE
DIPHENHYDRAMINE HYDROCHLORIDE

Manufacturer

Dosage forms

Spray/Inhaler, metered
Injectable, Solution, Capsule, Tablet

Drug class

Histamine-1 Receptor Antagonist
Histamine-1 Receptor Antagonist

Boxed warning

None
None

Treats

Allergic Conjunctivitis, Perennial Allergic Rhinitis, Vasomotor Rhinitis
Anxiety Disorders, Sleep Initiation and Maintenance Disorders, Motion Sickness

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Where to buy

Buy over-the-counter from trusted retailers.

Frequently asked questions

Which is cheaper, Astepro Allergy or Diphenhydramine Hydrochloride?

Diphenhydramine Hydrochloride costs pharmacies less to acquire — about $0.04 vs $0.58 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Astepro Allergy and Diphenhydramine Hydrochloride?

Astepro Allergy contains Azelastine Hydrochloride, while Diphenhydramine Hydrochloride contains Diphenhydramine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.