ALPRAZOLAM vs LORAZEPAM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 17, 2026·How we rate

Possible drug interaction. ALPRAZOLAM and LORAZEPAM are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ALPRAZOLAM	LORAZEPAM
Rating	66/100	70/100
Pharmacy pays	~$0.76 /30	~$1.14 /30
Type	RX	RX
Active ingredient	ALPRAZOLAM	LORAZEPAM
Manufacturer	Apotex	Ani Pharms
Dosage forms	Solution, Tablet, Tablet, extended release, Tablet, orally disintegrating	Injectable, Solution, Liquid, Tablet
Drug class	Benzodiazepine	Benzodiazepine
Boxed warning	None	Boxed warning
Half-life	about 11 hours (mean 11.2 hours; range roughly 6 to 27 hours) in healthy adults	about 12 hours (mean)
Treats	Agoraphobia, Depressive Disorder, Panic Disorder	Anxiety Disorders, Catatonia, Depressive Disorder

alprazolam lorazepam

Rating

66/100

70/100

Pharmacy pays

~$0.76 /30

~$1.14 /30

Type

Active ingredient

ALPRAZOLAM

LORAZEPAM

Manufacturer

Apotex

Ani Pharms

Dosage forms

Solution, Tablet, Tablet, extended release, Tablet, orally disintegrating

Injectable, Solution, Liquid, Tablet

Drug class

Benzodiazepine

Boxed warning

None

Boxed warning

Half-life

about 11 hours (mean 11.2 hours; range roughly 6 to 27 hours) in healthy adults

about 12 hours (mean)

Treats

Agoraphobia, Depressive Disorder, Panic Disorder

Anxiety Disorders, Catatonia, Depressive Disorder

Frequently asked questions

Which is better-rated, Alprazolam or Lorazepam?

By our independent rating, Lorazepam scores higher — 3.5 vs 3.3 out of 5 for Alprazolam. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Alprazolam or Lorazepam?

Alprazolam costs pharmacies less to acquire — about $0.76 vs $1.14 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Alprazolam and Lorazepam?

Alprazolam contains Alprazolam, while Lorazepam contains Lorazepam — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.