ADZENYS XR-ODT vs VYVANSE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. ADZENYS XR-ODT and VYVANSE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ADZENYS XR-ODT	VYVANSE
Rating	New	New
Pharmacy pays	~$478.55 /30	—
Type	RX	RX
Active ingredient	AMPHETAMINE	LISDEXAMFETAMINE DIMESYLATE
Manufacturer	Neos Theraps Inc	Takeda Pharms USA
Dosage forms	Tablet, orally disintegrating	Capsule, Tablet, chewable
Drug class	Central Nervous System Stimulant	Central Nervous System Stimulant
Boxed warning	Boxed warning	Boxed warning
Half-life	about 10 to 11 hours for d-amphetamine (range 9.8 to 11 hours) and about 12 to 14 hours for l-amphetamine (range 11.5 to 13.8 hours) in healthy adults	less than 1 hour (parent drug)
Treats	Attention Deficit Disorder with Hyperactivity, Narcolepsy	Attention Deficit Disorder with Hyperactivity, Binge Drinking

adzenys xr-odt vyvanse

Rating

New

Pharmacy pays

~$478.55 /30

—

Type

Active ingredient

AMPHETAMINE

LISDEXAMFETAMINE DIMESYLATE

Manufacturer

Neos Theraps Inc

Takeda Pharms USA

Dosage forms

Tablet, orally disintegrating

Capsule, Tablet, chewable

Drug class

Central Nervous System Stimulant

Boxed warning

Half-life

about 10 to 11 hours for d-amphetamine (range 9.8 to 11 hours) and about 12 to 14 hours for l-amphetamine (range 11.5 to 13.8 hours) in healthy adults

less than 1 hour (parent drug)

Treats

Attention Deficit Disorder with Hyperactivity, Narcolepsy

Attention Deficit Disorder with Hyperactivity, Binge Drinking

Frequently asked questions

What is the difference between Adzenys XR-ODT and Vyvanse?

Adzenys XR-ODT contains Amphetamine, while Vyvanse contains Lisdexamfetamine Dimesylate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.