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ADVIL vs LODINE XL

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 18, 2026·How we rate

Rating

72/100
New

Pharmacy pays

$0.04 /mL
~$22.58 /30

Type

OTC
RX

Active ingredient

IBUPROFEN
ETODOLAC

Dosage forms

Tablet, Capsule
Tablet, extended release

Drug class

Nonsteroidal Anti-Inflammatory Drug
Nonsteroidal Anti-Inflammatory Drug

Boxed warning

None
None

Half-life

about 1.8 to 2.0 hours
about 6.4 hours (roughly 6 to 8 hours; label reports a mean terminal half-life of 6.4 hours with 22% coefficient of variation)

Treats

Juvenile Arthritis, Rheumatoid Arthritis, Bursitis
Rheumatoid Arthritis, Osteoarthritis, Pain

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Where to buy

Buy over-the-counter from trusted retailers.

Frequently asked questions

What is the difference between Advil and Lodine XL?

Advil contains Ibuprofen, while Lodine XL contains Etodolac — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.