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ADVIL CONGESTION RELIEF vs IMODIUM MULTI-SYMPTOM RELIEF

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Rating

72/100
70/100

Pharmacy pays

$0.04 /mL
$0.05 /mL

Type

OTC
OTC

Active ingredient

IBUPROFEN AND PHENYLEPHRINE HYDROCHLORIDE
LOPERAMIDE HYDROCHLORIDE AND SIMETHICONE

Dosage forms

Tablet
Tablet

Drug class

Boxed warning

None
None

Half-life

about 1.8 to 2.0 hours
about 10.8 hours (range 9.1 to 14.4 hours)

Get advil congestion reliefhigher-rated option

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Where to buy

Buy over-the-counter from trusted retailers.

Frequently asked questions

Which is better-rated, Advil Congestion Relief or Imodium Multi-Symptom Relief?

By our independent rating, Advil Congestion Relief scores higher — 3.6 vs 3.5 out of 5 for Imodium Multi-Symptom Relief. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Advil Congestion Relief or Imodium Multi-Symptom Relief?

Advil Congestion Relief costs pharmacies less to acquire — about $0.04 vs $0.05 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Advil Congestion Relief and Imodium Multi-Symptom Relief?

Advil Congestion Relief contains Ibuprofen and Phenylephrine Hydrochloride, while Imodium Multi-Symptom Relief contains Loperamide Hydrochloride and Simethicone — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.