ADVIL COLD AND SINUS vs IMODIUM MULTI-SYMPTOM RELIEF

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Attribute	ADVIL COLD AND SINUS	IMODIUM MULTI-SYMPTOM RELIEF
Rating	72/100	70/100
Pharmacy pays	$0.04 /mL	$0.05 /mL
Type	OTC	OTC
Active ingredient	IBUPROFEN AND PSEUDOEPHEDRINE HYDROCHLORIDE	LOPERAMIDE HYDROCHLORIDE AND SIMETHICONE
Manufacturer	Haleon US Holdings	Kenvue Brands
Dosage forms	Capsule, Tablet	Tablet
Drug class	—	—
Boxed warning	None	None
Half-life	roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)	about 10.8 hours (range 9.1 to 14.4 hours)

advil cold and sinus imodium multi-symptom relief

Rating

72/100

70/100

Pharmacy pays

$0.04 /mL

$0.05 /mL

Type

OTC

Active ingredient

IBUPROFEN AND PSEUDOEPHEDRINE HYDROCHLORIDE

LOPERAMIDE HYDROCHLORIDE AND SIMETHICONE

Manufacturer

Haleon US Holdings

Kenvue Brands

Dosage forms

Capsule, Tablet

Tablet

Drug class

—

Boxed warning

None

Half-life

roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)

about 10.8 hours (range 9.1 to 14.4 hours)

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Frequently asked questions

Which is better-rated, Advil Cold and Sinus or Imodium Multi-Symptom Relief?

By our independent rating, Advil Cold and Sinus scores higher — 3.6 vs 3.5 out of 5 for Imodium Multi-Symptom Relief. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Advil Cold and Sinus or Imodium Multi-Symptom Relief?

Advil Cold and Sinus costs pharmacies less to acquire — about $0.04 vs $0.05 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Advil Cold and Sinus and Imodium Multi-Symptom Relief?

Advil Cold and Sinus contains Ibuprofen and Pseudoephedrine Hydrochloride, while Imodium Multi-Symptom Relief contains Loperamide Hydrochloride and Simethicone — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.