ADVIL COLD AND SINUS vs DURAPREP

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Attribute	ADVIL COLD AND SINUS	DURAPREP
Rating	72/100	New
Pharmacy pays	$0.04 /mL	—
Type	OTC	OTC
Active ingredient	IBUPROFEN AND PSEUDOEPHEDRINE HYDROCHLORIDE	IODINE POVACRYLEX AND ISOPROPYL ALCOHOL
Manufacturer	Haleon US Holdings	Solventum
Dosage forms	Capsule, Tablet	Solution
Drug class	—	—
Boxed warning	None	None
Half-life	roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)	—

advil cold and sinus duraprep

Rating

72/100

New

Pharmacy pays

$0.04 /mL

—

Type

OTC

Active ingredient

IBUPROFEN AND PSEUDOEPHEDRINE HYDROCHLORIDE

IODINE POVACRYLEX AND ISOPROPYL ALCOHOL

Manufacturer

Haleon US Holdings

Solventum

Dosage forms

Capsule, Tablet

Solution

Drug class

—

Boxed warning

None

Half-life

roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)

—

Get advil cold and sinushigher-rated option

Advertising disclosure: Some links are affiliate links. We may earn a commission at no extra cost to you. This never affects our independent ratings.

Where to buy

Buy over-the-counter from trusted retailers.

AmazonCheck price on Amazon

Frequently asked questions

What is the difference between Advil Cold and Sinus and Duraprep?

Advil Cold and Sinus contains Ibuprofen and Pseudoephedrine Hydrochloride, while Duraprep contains Iodine Povacrylex and Isopropyl Alcohol — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.