ACTONEL vs ZOMETA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. ACTONEL and ZOMETA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ACTONEL	ZOMETA
Rating	New	70/100
Pharmacy pays	~$73.02 /30	$0.47 /mL
Type	RX	RX
Active ingredient	RISEDRONATE SODIUM	ZOLEDRONIC ACID
Manufacturer	Apil	Novartis
Dosage forms	Tablet	Injectable
Drug class	Bisphosphonate	Bisphosphonate
Boxed warning	None	None
Half-life	about 561 hours — roughly 23 days	—
Treats	Extramammary Paget Disease, Postmenopausal Osteoporosis	Bone Neoplasms, Hypercalcemia, Multiple Myeloma

actonel zometa

Rating

New

70/100

Pharmacy pays

~$73.02 /30

$0.47 /mL

Type

Active ingredient

RISEDRONATE SODIUM

ZOLEDRONIC ACID

Manufacturer

Apil

Novartis

Dosage forms

Tablet

Injectable

Drug class

Bisphosphonate

Boxed warning

None

Half-life

about 561 hours — roughly 23 days

—

Treats

Extramammary Paget Disease, Postmenopausal Osteoporosis

Bone Neoplasms, Hypercalcemia, Multiple Myeloma

Frequently asked questions

What is the difference between Actonel and Zometa?

Actonel contains Risedronate Sodium, while Zometa contains Zoledronic Acid — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.