Progestin drugs compared

Compare all 9 Progestin drugs side by side, used for conditions such as anorexia, breast neoplasms, cachexia. They share one FDA-defined mechanism but differ in approved uses, prescription status, brand-vs-generic options, price, and FDA recall-safety record — which our independent rating scores. The highest-rated is megestrol acetate.

Top-rated progestin: 1. Megestrol Acetate · 2. Depo-Provera · 3. Depo-Subq Provera 104

Progestin drugs compared side by side, with pharmaranks' FDA recall-safety rating
Drug	Generic	Form	Status	Used for	Safety ratingFDA recall-based	Pharmacy pays
Megestrol Acetate	—	Tablet	Prescription	Anorexia, Breast Neoplasms	70/100	$7
Depo-Provera	Medroxyprogesterone Acetate	Injectable	Prescription	Amenorrhea, Breast Neoplasms	64/100	$563
Depo-Subq Provera 104	Medroxyprogesterone Acetate	Injectable	Prescription	Amenorrhea, Breast Neoplasms	64/100	$563
Provera	Medroxyprogesterone Acetate	Tablet	Prescription	Amenorrhea, Breast Neoplasms	64/100	$563
Liletta	Levonorgestrel	IUD	Prescription	—	Not yet rated	$192
Mirena	Levonorgestrel	IUD	Prescription	—	Not yet rated	$192
Nor-Qd	Norethindrone	Tablet	Prescription	Acne Vulgaris, Endometrial Hyperplasia	Not yet rated	$3
Plan B One-Step	Levonorgestrel	Tablet	Over-the-counter	—	Not yet rated	$192
Skyla	Levonorgestrel	IUD	Prescription	—	Not yet rated	$192

The safety rating column is unique to pharmaranks — an independent 0–100 score from FDA regulatory recall data. Higher is safer. Not medical advice.

Best progestin by condition

for breast neoplasms for amenorrhea for renal cell carcinoma

Full ranking · 9 drugs

Frequently asked questions

What is the Progestin drug class?

Progestin is an FDA Established Pharmacologic Class (EPC) — a group of drugs that share a mechanism of action. pharmaranks lists 9 Progestin products, each independently rated.

Are all Progestin drugs the same?

No. Progestin drugs share the same core mechanism — that is why they sit in one FDA class — but they differ in their approved uses, available forms, whether they are prescription or over-the-counter, brand-vs-generic options and price, and their FDA recall-safety record.

What conditions do Progestin drugs treat?

Per NIH RxClass drug-classification data, Progestin drugs are used for conditions including anorexia, breast neoplasms, cachexia, endometrial neoplasms, amenorrhea, carcinoma, renal cell.

Which Progestin drug is best-rated?

By our independent rating, megestrol acetate currently ranks highest among Progestin drugs. Ratings are based on FDA regulatory (recall-safety) data — always consult a professional.

Sources: the Progestin class definition and its member drugs come from the U.S. NLM RxClass (Established Pharmacologic Class); how the class works is summarized from Progestins - StatPearls - NCBI Bookshelf. Ratings are pharmaranks’ independent FDA recall-safety analysis.