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Best Progestin for breast neoplasms

Top-rated pick: Megestrol Acetate — pharmaranks score 70/100, the highest of the 4 Progestin drugs used for breast neoplasms, ranked by our independent FDA recall-safety score. Compare them with all treatments for breast neoplasms or the full Progestin class. Not medical advice — always consult a professional.

Quick answer: Of the 4 progestin drugs we rate for breast neoplasms, all are available as lower-cost generics, and most are tablet. Our ranking reflects each drug’s FDA recall-safety record — not clinical effectiveness for breast neoplasms; the right choice depends on your situation, so confirm it with your prescriber.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

How progestin work

Progestins are lab-made versions of the hormone progesterone. Acting through progesterone receptors, they quiet the brain signals that trigger ovulation, thicken cervical mucus so sperm cannot pass, and thin the uterine lining, which together help prevent pregnancy and regulate periods.

Source: Progestins - StatPearls - NCBI Bookshelf

Top progestin for breast neoplasms: 1. Megestrol Acetate · 2. Depo-Provera · 3. Depo-Subq Provera 104

Best-rated Progestin for breast neoplasms, ranked by pharmaranks score
#DrugRatingPharmacy pays
170/100$7View →
264/100$563View →
364/100$563View →
464/100$563View →

Full ranking · 4 drugs

Frequently asked

What is the best progestin for breast neoplasms?
By our independent recall-safety rating — not an efficacy measure — megestrol acetate ranks highest among Progestin drugs used for breast neoplasms. Always consult a professional.
Which progestin drugs treat breast neoplasms?
pharmaranks lists 4 Progestin products used for breast neoplasms, per NIH RxClass drug-classification data — each independently rated and ranked above.
How are these ranked?
By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.