Janus Kinase Inhibitor drugs compared

Compare all 11 Janus Kinase Inhibitor drugs side by side, used for conditions such as arthritis, rheumatoid, dermatitis, atopic, eczema. They share one FDA-defined mechanism but differ in approved uses, prescription status, brand-vs-generic options, price, and FDA recall-safety record — which our independent rating scores. The highest-rated is rinvoq.

Top-rated janus kinase inhibitor: 1. Rinvoq · 2. Rinvoq Lq · 3. Cibinqo

Janus Kinase Inhibitor drugs compared side by side, with pharmaranks' FDA recall-safety rating
Drug	Generic	Form	Status	Used for	Safety ratingFDA recall-based	Pharmacy pays
Rinvoq	Upadacitinib	Solution	Prescription	Arthritis, Rheumatoid	72/100	—
Rinvoq Lq	Upadacitinib	Solution	Prescription	Arthritis, Rheumatoid	72/100	—
Cibinqo	Abrocitinib	Tablet	Prescription	Dermatitis, Atopic	64/100	—
Xeljanz	Tofacitinib Citrate	Solution	Prescription	Arthritis, Rheumatoid	64/100	—
Anzupgo	Delgocitinib	Topical	Prescription	Eczema	Not yet rated	—
Jakafi	Ruxolitinib Phosphate	Tablet	Prescription	Polycythemia Vera, Primary Myelofibrosis	Not yet rated	—
Jakafi XR	Ruxolitinib Phosphate	Tablet	Prescription	Polycythemia Vera, Primary Myelofibrosis	Not yet rated	—
Leqselvi	Deuruxolitinib Phosphate	Tablet	Prescription	Alopecia Areata	Not yet rated	—
Olumiant	Baricitinib	Tablet	Prescription	Arthritis, Rheumatoid	Not yet rated	—
Opzelura	Ruxolitinib Phosphate	Topical	Prescription	Polycythemia Vera, Primary Myelofibrosis	Not yet rated	—
Tofacitinib Citrate	—	Tablet	Prescription	Arthritis, Rheumatoid	Not yet rated	—

The safety rating column is unique to pharmaranks — an independent 0–100 score from FDA regulatory recall data. Higher is safer. Not medical advice.

Best janus kinase inhibitor by condition

for rheumatoid arthritis for polycythemia vera for primary myelofibrosis

Full ranking · 11 drugs

Frequently asked questions

What is the Janus Kinase Inhibitor drug class?

Janus Kinase Inhibitor is an FDA Established Pharmacologic Class (EPC) — a group of drugs that share a mechanism of action. pharmaranks lists 11 Janus Kinase Inhibitor products, each independently rated.

Are all Janus Kinase Inhibitor drugs the same?

No. Janus Kinase Inhibitor drugs share the same core mechanism — that is why they sit in one FDA class — but they differ in their approved uses, available forms, whether they are prescription or over-the-counter, brand-vs-generic options and price, and their FDA recall-safety record.

What conditions do Janus Kinase Inhibitor drugs treat?

Per NIH RxClass drug-classification data, Janus Kinase Inhibitor drugs are used for conditions including arthritis, rheumatoid, dermatitis, atopic, eczema, polycythemia vera, primary myelofibrosis, alopecia areata.

Which Janus Kinase Inhibitor drug is best-rated?

By our independent rating, rinvoq currently ranks highest among Janus Kinase Inhibitor drugs. Ratings are based on FDA regulatory (recall-safety) data — always consult a professional.

Sources: the Janus Kinase Inhibitor class definition and its member drugs come from the U.S. NLM RxClass (Established Pharmacologic Class); how the class works is summarized from Janus kinase-targeting therapies in rheumatology: a mechanisms-based approach - PMC, NCBI. Ratings are pharmaranks’ independent FDA recall-safety analysis.