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GLP-1 drugs compared

Compare all 7 GLP-1 drugs side by side, used for conditions such as diabetes mellitus, type 2, obesity, overweight. GLP-1 drugs are the GLP-1 Receptor Agonist class. They share one FDA-defined mechanism but differ in approved uses, prescription status, brand-vs-generic options, price, and FDA recall-safety record — which our independent rating scores. The highest-rated is ozempic.

Top-rated GLP-1 receptor agonist: 1. Ozempic · 2. Rybelsus · 3. Saxenda

GLP-1 Receptor Agonist drugs compared side by side, with pharmaranks' FDA recall-safety rating
DrugGenericSafety ratingFDA recall-based
OzempicSemaglutide70/100
RybelsusSemaglutide70/100
SaxendaLiraglutide70/100
VictozaLiraglutide70/100
WegovySemaglutide70/100
MounjaroTirzepatideNot yet rated
ZepboundTirzepatideNot yet rated

The safety rating column is unique to pharmaranks — an independent 0–100 score from FDA regulatory recall data. Higher is safer. Not medical advice.

Best GLP-1 receptor agonist by condition

for type 2 diabetes mellitusfor obesityfor overweight

Full ranking · 7 drugs

  1. 1

    ozempic

    Semaglutide

    70/100
  2. 2

    rybelsus

    Semaglutide

    70/100
  3. 3

    saxenda

    Liraglutide

    70/100
  4. 4

    victoza

    Liraglutide

    70/100
  5. 5

    wegovy

    Semaglutide

    70/100
  6. 6

    mounjaro

    Tirzepatide

    New
  7. 7

    zepbound

    Tirzepatide

    New

Frequently asked questions

What is the GLP-1 Receptor Agonist drug class?

GLP-1 Receptor Agonist is an FDA Established Pharmacologic Class (EPC) — a group of drugs that share a mechanism of action. pharmaranks lists 7 GLP-1 Receptor Agonist products, each independently rated.

Are all GLP-1 Receptor Agonist drugs the same?

No. GLP-1 Receptor Agonist drugs share the same core mechanism — that is why they sit in one FDA class — but they differ in their approved uses, available forms, whether they are prescription or over-the-counter, brand-vs-generic options and price, and their FDA recall-safety record.

Is "GLP-1 drugs" the same as the GLP-1 Receptor Agonist class?

Yes — "GLP-1 drugs" is the everyday name for the GLP-1 Receptor Agonist drug class. This page compares the 7 GLP-1 drugs pharmaranks rates, with our independent FDA recall-safety score for each.

What conditions do GLP-1 Receptor Agonist drugs treat?

Per NIH RxClass drug-classification data, GLP-1 Receptor Agonist drugs are used for conditions including diabetes mellitus, type 2, obesity, overweight.

Which GLP-1 Receptor Agonist drug is best-rated?

By our independent rating, ozempic currently ranks highest among GLP-1 Receptor Agonist drugs. Ratings are based on FDA regulatory (recall-safety) data — always consult a professional.

Sources: the GLP-1 Receptor Agonist class definition and its member drugs come from the U.S. NLM RxClass (Established Pharmacologic Class); how the class works is summarized from Glucagon-Like Peptide-1 Receptor Agonists - StatPearls - NCBI Bookshelf. Ratings are pharmaranks’ independent FDA recall-safety analysis.