Best Progestin for endometrial hyperplasia
Top-rated pick: Depo-Provera — pharmaranks score 64/100, the highest of the 4 Progestin drugs used for endometrial hyperplasia, ranked by our independent FDA recall-safety score. Compare them with all treatments for endometrial hyperplasia or the full Progestin class. Not medical advice — always consult a professional.
Quick answer: Of the 4 progestin drugs we rate for endometrial hyperplasia, all are available as lower-cost generics, and most are injectable. Our ranking reflects each drug’s FDA recall-safety record — not clinical effectiveness for endometrial hyperplasia; the right choice depends on your situation, so confirm it with your prescriber.
How progestin work
Progestins are lab-made versions of the hormone progesterone. Acting through progesterone receptors, they quiet the brain signals that trigger ovulation, thicken cervical mucus so sperm cannot pass, and thin the uterine lining, which together help prevent pregnancy and regulate periods.
Other drug classes for endometrial hyperplasia
Top progestin for endometrial hyperplasia: 1. Depo-Provera · 2. Depo-Subq Provera 104 · 3. Provera
| # | Drug | Rating | Type | Form | Generic? | Pharmacy pays | |
|---|---|---|---|---|---|---|---|
| 1 | 64/100 | Prescription | Injectable | Generic | $563 | View → | |
| 2 | 64/100 | Prescription | Injectable | Generic | $563 | View → | |
| 3 | 64/100 | Prescription | Tablet | Generic | $563 | View → | |
| 4 | Not yet rated | Prescription | Tablet | Generic | $3 | View → |
Full ranking · 4 drugs
depo-provera
Boxed warningPrescriptionFDA-sourced
Depo-Provera (Medroxyprogesterone Acetate) is a progestin used to treat Amenorrhea, Breast Neoplasms, Renal Cell Carcinoma, Endometrial Hyperplasia.
Pharmacy pays
From ~$3.49/30· 4 forms Save up to 99% in classdepo-subq provera 104
Boxed warningPrescriptionFDA-sourced
Depo-Subq Provera 104 (Medroxyprogesterone Acetate) is a progestin used to treat Amenorrhea, Breast Neoplasms, Renal Cell Carcinoma, Endometrial Hyperplasia.
Pharmacy pays
From ~$3.49/30· 4 forms Save up to 99% in classprovera
Boxed warningPrescriptionFDA-sourced
Provera (Medroxyprogesterone Acetate) is a progestin used to treat Amenorrhea, Breast Neoplasms, Renal Cell Carcinoma, Endometrial Hyperplasia.
Pharmacy pays
From ~$3.49/30· 4 forms Save up to 99% in classnor-qd
PrescriptionFDA-sourced
Nor-Qd (Norethindrone) is a progestin used to treat Acne Vulgaris, Endometrial Hyperplasia, Endometriosis, Hypogonadism.
Pharmacy pays
From ~$2.80/30· 2 formsFrequently asked
- What is the best progestin for endometrial hyperplasia?
- By our independent recall-safety rating — not an efficacy measure — depo-provera ranks highest among Progestin drugs used for endometrial hyperplasia. Always consult a professional.
- Which progestin drugs treat endometrial hyperplasia?
- pharmaranks lists 4 Progestin products used for endometrial hyperplasia, per NIH RxClass drug-classification data — each independently rated and ranked above.
- How are these ranked?
- By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.