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Best Folate Analog Metabolic Inhibitor for crohn disease

Top-rated pick: Xatmep — pharmaranks score 70/100, the highest of the 5 Folate Analog Metabolic Inhibitor drugs used for crohn disease, ranked by our independent FDA recall-safety score. Compare them with all treatments for crohn disease or the full Folate Analog Metabolic Inhibitor class. Not medical advice — always consult a professional.

Quick answer: Of the 5 folate analog metabolic inhibitor drugs we rate for crohn disease, all are available as lower-cost generics, and most are injectable. Our ranking reflects each drug’s FDA recall-safety record — not clinical effectiveness for crohn disease; the right choice depends on your situation, so confirm it with your prescriber.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

How folate analog metabolic inhibitor work

Folate analog metabolic inhibitors like methotrexate block the enzyme that converts folate into its usable form, starving fast-dividing cells of the building blocks for DNA. At low doses they also calm an overactive immune system and reduce inflammation.

Source: Methotrexate - StatPearls - NCBI Bookshelf

Top folate analog metabolic inhibitor for crohn disease: 1. Xatmep · 2. Methotrexate Lpf · 3. Methotrexate Preservative Free

Best-rated Folate Analog Metabolic Inhibitor for crohn disease, ranked by pharmaranks score
#DrugRatingPharmacy pays
170/100$5View →
254/100$5View →
354/100$5View →
4Not yet rated$5View →
5Not yet rated$5View →

Full ranking · 5 drugs

#1 of 4 in Folate Analog Metabolic Inhibitor

xatmep

Boxed warning

PrescriptionFDA-sourced

70/100

Xatmep (Methotrexate Sodium) is a folate analog metabolic inhibitor used to treat Juvenile Arthritis, Rheumatoid Arthritis, Breast Neoplasms, Choriocarcinoma.

(3 data points)
folate analog metabolic inhibitorarthritis, juvenilearthritis, rheumatoid

Pharmacy pays

From ~$4.81/30· 3 forms
View details →
#3 of 4 in Folate Analog Metabolic Inhibitor

methotrexate lpf

Boxed warning

PrescriptionFDA-sourced

54/100

Methotrexate Lpf (Methotrexate Sodium) is a folate analog metabolic inhibitor used to treat Juvenile Arthritis, Rheumatoid Arthritis, Breast Neoplasms, Choriocarcinoma.

(88 data points)
folate analog metabolic inhibitorarthritis, juvenilearthritis, rheumatoid

Pharmacy pays

From ~$4.81/30· 3 forms
View details →
#3 of 4 in Folate Analog Metabolic Inhibitor

methotrexate preservative free

Boxed warning

PrescriptionFDA-sourced

54/100

Methotrexate Preservative Free (Methotrexate Sodium) is a folate analog metabolic inhibitor used to treat Juvenile Arthritis, Rheumatoid Arthritis, Breast Neoplasms, Choriocarcinoma.

(88 data points)
folate analog metabolic inhibitorarthritis, juvenilearthritis, rheumatoid

Pharmacy pays

From ~$4.81/30· 3 forms
View details →

jylamvo

Boxed warning

PrescriptionFDA-sourced

New

Jylamvo (Methotrexate) is a folate analog metabolic inhibitor used to treat Juvenile Arthritis, Rheumatoid Arthritis, Breast Neoplasms, Choriocarcinoma.

folate analog metabolic inhibitorarthritis, juvenilearthritis, rheumatoid

Pharmacy pays

From ~$4.81/30· 3 forms
View details →

rasuvo

Boxed warning

PrescriptionFDA-sourced

New

Rasuvo (Methotrexate) is a folate analog metabolic inhibitor used to treat Juvenile Arthritis, Rheumatoid Arthritis, Breast Neoplasms, Choriocarcinoma.

folate analog metabolic inhibitorarthritis, juvenilearthritis, rheumatoid

Pharmacy pays

From ~$4.81/30· 3 forms
View details →

Frequently asked

What is the best folate analog metabolic inhibitor for crohn disease?
By our independent recall-safety rating — not an efficacy measure — xatmep ranks highest among Folate Analog Metabolic Inhibitor drugs used for crohn disease. Always consult a professional.
Which folate analog metabolic inhibitor drugs treat crohn disease?
pharmaranks lists 5 Folate Analog Metabolic Inhibitor products used for crohn disease, per NIH RxClass drug-classification data — each independently rated and ranked above.
How are these ranked?
By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.